et al., 2011). Polymorphisms in adducins affect cognitive functions in individuals with schizophrenia (Bosia et al., 2016). NBN (nibrin) affects neuronal proliferation and differentiation (Lee et al., 2007). Mutations in NBN cause Nijmegen breakage syndrome, characterized by progressive microcephaly, growth retardation, and predisposition to cancer (Varon et al., 1998). PKD1L2 (polycystin 1 like 2) upregulation leads to a complex neuromuscular disease in mice (Mackenzie et al., 2009); it forms part of an ion channel in cilia of some cell types (DeCaen et al., 2013). Mutation of SIRPA (signal regulatory protein alpha) protected mice from oxidative stress and brain ischemia (Wang et al., 2012).
