Among the many genes in which multiple SNPs in the 3’UTR affected expression, some have relevant phenotypes. KIF6 (kinesin family member 6), expressed in several regions of the brain, including amygdala, caudate, hippocampus and putamen, encodes a molecular motor involved in intracellular transport. It plays a role in ciliogenesis in vertebrate ependymal cell (specialized glial cells that forms the epithelial lining of the ventricular walls of the brain and spinal canal), and a frameshift mutation in KIF6 was found in a child who displayed neurodevelopmental defects and intellectual disability (Konjikusic et al., 2018). A rare variant in KIF6 was reported to play a role in some sudden unexpected deaths in people with epilepsy (Ge et al., 2020). ADD2 (adducin 2) encodes a cytoskeleton associated protein involved in synaptic plasticity; alcohol exposure at early neurulation alters the expression of ADD2 (Zhou et al., 2011). Polymorphisms in adducins affect cognitive functions in individuals with schizophrenia (Bosia et al., 2016). NBN (nibrin) affects neuronal proliferation and differentiation (Lee et al., 2007). Mutations in NBN cause Nijmegen breakage syndrome, characterized by progressive microcephaly, growth
