The impact of alcohol use on Aβ and Tau pathology in specific brain regions and association with and cognitive function is not fully understood. To address this gap in knowledge, we conducted a set of translational studies in 3xTg-AD mice designed to test the overall hypothesis that voluntary alcohol drinking exacerbates the onset and magnitude of AD-related neural and behavioral pathology (Fig. 2B). These studies can provide significant public health information for approximately 80% of adults who have consumed alcohol in a nondependent manner. Moreover, understanding the impact of alcohol drinking on AD pathology has potential to lead to novel diagnostic, prevention, and treatment options for this large segment of the population.
