Male (n = 7) and female (n = 3) 3xTg-AD (B6;129-Tg(APPSwe,TauP301L) 1Lfa PSEN-1tm1Mpm/Mmjax) triple-transgenic homozygous mice were used in these studies. The 3xTg-AD mouse line was generated by Dr. Frank LaFerla at UC Irvine (Oddo, Caccamo, Shepherd, et al., 2003) and provided for use in these studies via the Mutant Mouse Resource & Research Center Repository (MMRRC stock #34830) at Jackson Labs (Bar Harbor, ME) under an approved Material Transfer Agreement with UC Irvine. Background strain- and sex-matched B6129SF2/J mice (male [n = 7] and female [n = 3]) were used as wild-type (WT) controls where appropriate. Data from male and female mice were combined but due to low sample size, methods were underpowered to detect sex differences.
