Based on the findings in our initial study and on the significant association signal observed here at SNP8, we performed an interaction analysis between SNP8^T/T and SNP3^G+ (G/G and G/T for SNP3), which conferred significantly higher risk for CD (P=0.015, Table 2). Additionally, exhaustively analyzing two-way marker-marker interactions showed that SNP8^T/T had no significant interaction with the other markers (except for SNP3) in CNR1 (P>0.05). As showed in Figure 1, SNP3 and SNP8 are neither in LD (D’= 0.026) nor correlated with each other (r2=0).
