Chunk #20 — Results — Associations of CNR1 with CD in the EA family sample

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Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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In the global haplotype association test, the frequency distribution of SNP8-containing haplotypes (constructed from three SNPs within the haplotype block that contains SNP8) in CD cases differed significantly from controls (Pglobal=0.007, with α=0.017). Moving the haplotype window in the 5’ or 3’ direction in CNR1, this association signal decreased (data not shown). We failed to observe an association between SNP3-containing haplotypes and CD.