Chunk #9 — Method — Measures — Genotyping and genome-wide polygenic scores

Source

Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.

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Consistent with prior research, we account for the first 10 genetic ancestry principal components (PC1-PC10) to adjust for potential population stratification. Specifically, we created residualized alc-PRS scores that account for PC1-PC10. The residualized alc-PRS scores were then standardized by creating Z-scores for subsequent analyses to aid in interpretation of results.