Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.
paper
Primary
Public
- Authors
- Su, Jinni; Kuo, Sally I-Chun; Aliev, Fazil; Rabinowitz, Jill A; Jamil, Belal; Chan, Grace; Edenberg, Howard J; Francis, Meredith; Hesselbrock, Victor; Kamarajan, Chella; Kinreich, Sivan; Kramer, John; Lai, Donbing; McCutcheon, Vivia; Meyers, Jacquelyn; Pandey, Ashwini; Pandey, Gayathri; Plawecki, Martin H; Schuckit, Marc; Tischfield, Jay; Dick, Danielle M
- Year
- 2023
- Journal
- Development and psychopathology
- PMID
- 37781861
- DOI
- 10.1017/S0954579423001141
- PMCID
- PMC10985050
Alcohol use is influenced by genetic and environmental factors. We examined the interactive effects between genome-wide polygenic risk scores for alcohol use (alc-PRS) and social support in relation to alcohol use among European American (EA) and African American (AA) adults across sex and developmental stages (emerging adulthood, young adulthood, and middle adulthood). Data were drawn from 4,011 EA and 1,274 AA adults from the Collaborative Study on the Genetics of Alcoholism who were between ages 18-65 and had ever used alcohol. Participants completed the Semi-Structured Assessment for the Genetics of Alcoholism and provided saliva or blood samples for genotyping. Results indicated that social support from friends, but not family, moderated the association between alc-PRS and alcohol use among EAs and AAs (only in middle adulthood for AAs); alc-PRS was associated with higher levels of alcohol use when friend support was low, but not when friend support was high. Associations were similar across sex but differed across developmental stages. Findings support the important role of social support from friends in buffering genetic risk for alcohol use among EA and AA adults and highlight the need to consider developmental changes in the role of social support in relation to alcohol use.
Alc-PRS by friend support interaction in relation to alcohol use among European Americans. Predicted values of log-transformed alcohol use (drinks per week) are plotted at prototypical values (+1/−1 SD) of alc-PRS and friend support.
LLM interpretation
This line graph shows the interaction between alcohol polygenic risk score (Alc-PRS) and friend support on log-transformed alcohol use among European Americans. As Alc-PRS increases from low (-1 SD) to high (+1 SD), alcohol use increases for both groups, but the increase is more pronounced for those with low friend support ($\beta = .15, p < .001$) compared to those with high friend support ($\beta = .06, p = .011$). The y-axis represents alcohol use, and the x-axis represents the Alc-PRS levels.
Alc-PRS by friend support interaction in relation to alcohol use among African Americans in middle adulthood. Predicted values of log-transformed alcohol use (drinks per week) are plotted at prototypical values (+1/−1 SD) of alc-PRS and friend support.
LLM interpretation
This line graph illustrates the interaction between alcohol polygenic risk score (Alc-PRS) and friend support on log-transformed alcohol use. For individuals with low friend support (solid line), higher Alc-PRS is associated with increased alcohol use ($\beta = .19, p = .003$). Conversely, for those with high friend support (dashed line), there is a non-significant trend toward decreased alcohol use as Alc-PRS increases ($\beta = -.10, p = .097$).
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| Name | Type |
|---|---|
| 1000 Genomes local | drug |
| AA | cohort |
| AA middle adults local | cohort |
| AA participants | cohort |
| AA sample | cohort |
| adults | cohort |
| African American | cohort |
| African-Americans | cohort |
| African ancestry (AAs) local | cohort |
| African ancestry (AA) subsample local | cohort |
| age | phenotype |
| age group | cohort |
| alcohol | phenotype |
| Alcohol consumption (AUDIT-C) local | phenotype |
| alcohol dependence | phenotype |
| alcohol phenotype (drinks per week) local | phenotype |
| Alcohol polygenic risk score local | drug |
| Alcohol Use | phenotype |
| alcohol use disorders | phenotype |
| alc-PRS local | drug |
| alc-PRS local | phenotype |
| alc-PRS local | variant |
| Alc-PRS local | phenotype |
| Ancestral groups local | cohort |
| AUDIT-C | phenotype |
| beer | drug |
| COGA Phase II local | cohort |
| COGA sample | cohort |
| Collaborative Study on the Genetics of Alcoholism (COGA) | cohort |
| developmental age groups local | cohort |
| Developmental differences local | phenotype |
| developmental stage | phenotype |
| DNA sample provision local | phenotype |
| drinking | phenotype |
| drinks per week | phenotype |
| EA participants | cohort |
| EAs | cohort |
| East Asian | cohort |
| EA subsample local | cohort |
| educational attainment | phenotype |
| emerging adulthood | cohort |
| emerging adults (18-21) local | cohort |
| emerging adults (22-29) local | cohort |
| European ancestry | cohort |
| European ancestry (EAs) local | cohort |
| European ancestry (EA) sample local | cohort |
| Extended families enriched for alcohol use disorders local | cohort |
| family/friend support local | phenotype |
| family support local | drug |
| family support | phenotype |
| Family support local | drug |
| friends local | cohort |
| friend support local | drug |
| friend support local | phenotype |
| Friend support local | drug |
| Friend support local | phenotype |
| full sample | cohort |
| G×E effects local | variant |
| genetic risk | cohort |
| GSCAN GWAS sample local | cohort |
| GWAS & Sequencing Consortium of Alcohol and Nicotine use | cohort |
| high-risk adult alcohol users local | cohort |
| High-risk adult alcohol users local | cohort |
| Illumina 2.5M array | drug |
| Illumina Human1M array | drug |
| Illumina Human OmniExpress 12V1 array | drug |
| income | phenotype |
| liquor | drug |
| men | cohort |
| middle adulthood | phenotype |
| middle adults (45-55) local | cohort |
| middle adults (56-65) local | cohort |
| middle-aged adults | cohort |
| Million Veteran Program | cohort |
| Million Veterans Project (MVP) local | cohort |
| Minimac 3 local | drug |
| MVP | cohort |
| MVP EA local | cohort |
| MVP EA sample local | cohort |
| MVP sample | cohort |
| nicotine | drug |
| non-European ancestry | cohort |
| Other alcoholic beverage local | drug |
| PC1-PC10 local | cohort |
| Perceived Social Support from Family/Friends Scale local | phenotype |
| Perceived Social Support from Family Scale local | phenotype |
| Perceived Social Support from Friends Scale local | phenotype |
| psychiatric traits | phenotype |
| relationship satisfaction | phenotype |
| romantic partners local | cohort |
| sex | phenotype |
| sex differences | phenotype |
| SHAPPEIT2 local | drug |
| Smokescreen genotyping array | drug |
| social support | phenotype |
| Social support from family local | phenotype |
| social support from friends local | phenotype |
| Social support from friends local | phenotype |
| spouses | cohort |
| Standard drinks per week local | phenotype |
| wine | drug |
| women | cohort |
| young adults | cohort |
| young adults (30-37) local | cohort |
| young adults (38-44) local | cohort |
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Social support is not enough to buffer the effects of stressors on substance use at midlife. | Moilanen KL et al. | — | 2025 | → |
| Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. | Li X et al. | — | 2024 | → |