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Chunk #30 — Results — Overall ability to detect eQTLs depends on tissue type and gene expression

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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.
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We next compared the proportions of eQTLs found in the three sample series and considered whether these were associated with brain, blood or other phenotypes (Table 1). In the analysis restricted to probes detected in both blood and brain tissues, 125 eQTLs were found within 500 KB of any GWA SNP in blood, versus 40 eQTLs found in the brain dataset. Of these, 21 significant eQTLs were found in the blood dataset for blood traits, while 16 eQTLs were found in blood for brain traits. Six significant eQTLs were found in the brain, counting either cerebellum or frontal cortex, for brain traits and an additional six eQTLs were found in brain for blood traits out of 40 total significant associations. The proportions of blood and brain traits with detected eQTLs were similar in blood and brain samples (two tailed Z-test, P = 0.18, 1.0 respectively).