this impact, we performed an analysis examining the abstinence rates at 6-month follow-up restricted to only those individuals abstinent at EOT (n = 112). For rs2072661, the P-value from the 2 degree-of-freedom LRT was 0.047. Of note, for those individuals who received bupropion, the impact of rs2072661 was substantial for decreasing the odds of quitting, once the individuals were no longer on treatment (OR = 0.25; 95% CI 0.08–0.78).