To demonstrate more clearly the impact of SNP rs2072661 on the abstinence rates, we examined in more detail the patterns of relapse from EOT to 6-month follow-up. Figure 2 presents the abstinence rates for all the individuals and stratified by rs2072661. As reflected in the odds ratio estimates for the genetic effect, the abstinence rates are lower for those individuals who carry the minor allele (AA or AG). This impact is greater at 6-month follow-up. Interestingly, from EOT to 6-month follow-up, individuals carrying the minor allele who had received bupropion during the treatment phase had the greatest reduction in abstinence once treatment ended. While not statistically significant (P = 0.10), for all the individuals carrying the minor allele who were treated with bupropion, the abstinence rate was 22.4% at EOT and decreased to 10.6% at 6-month follow-up. To further quantify this impact, we performed an analysis examining the abstinence rates at 6-month follow-up restricted to only those individuals abstinent at EOT (n = 112). For rs2072661, the P-value from the 2 degree-of-freedom LRT was 0.047. Of note, for those individuals
