Overall, there were five SNP-trait associations that generalized to African descent populations with respect to both level of significance (p<0.05) and direction of effect: for heart rate rs4352210 (intergenic, β= −1.6, p= 0.03), for QTc interval, rs1112795 (SCN5A, β = − 4.77; p=0.05) and rs4725982 (KCNH2, β = 4.79; p=0.03), and for QRS duration, rs6795970 (SCN10A, β = 2.43; p=0.01) and rs11710077 (SCN5A, β= 2.42; p=0.004) (Table 3). No SNPs generalized for PR interval. There were six additional SNP-trait associations from the GWAS catalog that were significant (p-value <0.05) but trended in the opposite direction in African Americans compared with European-descent populations (after accounting for the coded allele): four for PR interval, three for heart rate, and one for QT interval (Supplementary Table 1).
