An additional 40 SNP-trait associations failed to achieve the liberal threshold of significance (p<0.05) in African Americans but did have consistent directions of effect compared with European-descent populations (Supplementary Table 2, Fig. 1). Based solely on direction of effect, approximately 50% and 52% of the associations tested for PR and QT intervals, respectively, have a consistent direction of effect in African Americans compared with European descent populations. For QRS duration, 37% of the associations tested generalized in African Americans while 44% generalized for heart rate. Collectively, 44 out of 92 (47%) SNP-trait associations had a consistent direction effect regardless of significance in African Americans compared to previously identified associations in European-descent populations. The remaining 48/92 (52%) SNP-trait associations identified in European-descent populations did not generalize to African Americans with respect to either level of significance or direction of effect.
