At 31 of the 33 loci, ORs in the psychosis follow-up group were in the same direction as in the discovery data set (SGENE-plus+ISC+MGS) (Supplementary Table 3). A similar pattern had been observed in the schizophrenia follow-up set—ORs were in the same direction at 30 of the 33 loci14. These results indicate that the set of variants chosen for follow-up was enriched for risk alleles (P = 7.0 × 10−7 for schizophrenia, and P = 6.5 × 10−8 for psychosis).
