Furthermore, CREMα has been demonstrated to contribute to antithetic expression patterns in naïve and effector T lymphocytes through epigenetic remodeling processes [34]. However, it remains to be determined whether CREMα plays a role during the differentiation towards Th17 subset or whether CREMα rather plays a role in the tissue-specific expression of IL-17 and the silencing of IL-2 in non-naïve T lymphocyte subsets. This question will need to be addressed in genetically modified systems.
