We previously demonstrated that the expression of CREMα is regulated by several mechanisms, including differential trans-activation of the CREM promoters and/or epigenetic remodeling of the promoter P1 [24,32,34]. However, the molecular mechanisms that mediate CpG-DNA de-methylation in effector T cells and T lymphocytes from SLE patients remain to be determined. Furthermore, the alternative splicing mechanisms that favor the production of CREMα over other CREM isoforms will be the focus of future research.
