Chunk #68 — Methods — Rank-rank hypergeometric overlap (RRHO)

Source

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.

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To compare gene-level overlaps (RRHO output) with genetic correlations (calculated by LDSC), P-values from RRHO was converted into Z-scores using the following command line: Zscore = qnorm(10^(-Pvalues), lower.tail=FALSE)