Chunk #69 — Methods — Rank-rank hypergeometric overlap (RRHO)

Source

A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.

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We then compared resulting RRHO Z-scores with rg values from the genetic correlation analysis using Pearson’s correlation. This correlation coefficient provides a metric to compare a genetic relationship between two disorders measured at the SNP level (rg) vs. gene-level (RRHO Z).