A secondary analysis was conducted to examine potential interactions of PTSD and FKBP5 on cingulum connectivity. After covarying age and depressive symptoms, factorial ANCOVA results indicated a significant interaction of genotype and PTSD diagnosis (F1,37=4.52, p=.04; see Figure 2). Individuals with a PTSD diagnosis who carried 2 FKBP5 risk alleles (TT genotype with PTSD, n=6)) demonstrated the lowest cingulum FA values compared to individuals with this genotype without PTSD (n=11), and CC/CT genotypes both with (n=5) and without PTSD (n=21).
