No differences in resting-state connectivity were found between participants with and without PTSD (p>.05). However, t-test results indicated that carriers of the CC/CT genotypes (n=24) demonstrated significantly greater functional coupling between the hippocampi and ACC compared to carriers of the TT genotype (p<.05). Factorial ANCOVA was not conducted due to the limited numbers of participants with PTSD in this subset (n=7). Results of a correlational analysis indicated that cingulum FA positively correlated with resting state functional connectivity between the hippocampi and regions of the ACC (r=.5, p=.005; Figure 3). A whole-brain analysis was conducted to examine functional connectivity of the hippocampus with other brain regions. When cingulum FA was used as a regressor, there was a significant association between the cingulum FA and the hippocampal functional connectivity at rest in the ACC but not other regions, after correcting for multiple comparisons (p<.05, corrected).
