Together, these findings highlight the value of ancestrally diverse genetic studies to prioritize the study of pathophysiological processes in MD. The clearer association of genetic variants with altered gene expression and the enrichment of antidepressant targets provide confidence that genetic association findings will be relevant to the development, deployment, or repurposing of pharmacotherapies. Critically, these findings suggest genetic associations will point to new drug targets and more effective therapies that may reduce the considerable disability caused by depression.
