The current meta-analysis is limited by the low proportion of participants of non-European ancestries (76.6% of people with MD were of European ancestry) who were genotyped using arrays developed in European populations. This may reduce the power to discover or test the cross-ancestry transferability of genetic variants. Without larger and more globally representative samples, it is not clear whether (or to what extent) the genetic architecture of MD differs by ancestry or whether there are genetic differences between ancestral populations recruited from their regional origin versus those recruited from diasporas.
