Studies have also examined DTI- function relationships in alcoholism. FA in anterior cingulate and motor areas correlates with executive and psychomotor performance (Konrad et al. 2012), FA in the splenium correlates with working memory (Pfefferbaum et al. 2000), and FA in several regions (corpus callosum, parietal, occipital, and frontal white-matter) correlates with performance on the Iowa Gambling Task (Zorlu et al. 2013). A double dissociation was found showing that higher diffusivity in sensory- motor and parietal bundles was associated with poorer balance but not psychomotor speed, whereas higher diffusivity in prefrontal and temporal bundles was associated with slower psychomotor speed but not balance (Pfefferbaum et al. 2010). DTI changes in multiple supratentorial and infratentorial fiber systems in alcoholics correlated with impairment in speeded performance and postural stability (Pfefferbaum et al. 2009b), frontal fiber integrity connecting left and right hemispheres predicted performance on a coordinated psychomotor task (Rosenbloom et al. 2008), and number of reconstructed fibers running between the pons and the midbrain was related to cognitive flexibility performance (Chanraud et al. 2009b). Gray-matter diffusivity in the hippocampus, which is lower in alcoholics than in healthy controls, is related to episodic memory impairment (Chanraud et al. 2009a).
