DTI has revealed microstructural damage related to alcoholism in cerebral areas that appear intact in structural MRI analyses (e.g., Pfefferbaum and Sullivan 2002; Pfefferbaum et al. 2006b; Sullivan et al. 2003). Corpus callosum findings in uncomplicated alcoholics are common and, as observed for MBD, show greater anterior than posterior effects (e.g., Arnone et al. 2006; Konrad et al. 2012; Liu et al. 2010; Pitel et al. 2010; Schulte et al. 2005). Quantitative fiber tracking has demonstrated greater FA deficits in anterior than in posterior fibers of supratentorial and infratentorial white-matter bundles in alcoholics compared with healthy controls, as well as low FA in tracts of the corpus callosum, centrum semiovale, internal and external capsules, fornix, superior cingulate, and longitudinal fasciculi (Fortier et al. 2014; Müller-Oehring et al. 2009; Pfefferbaum and Sullivan 2005; Pfefferbaum et al. 2000, 2002a, 2009a; Trivedi et al. 2013). Frontolimbic (Harris et al. 2008; Monnig et al. 2013), fronto-parietal (Maksimovskiy et al. 2014), fronto-occipital (Bagga et al. 2014), fronto-cerebellar (Sullivan and Pfefferbaum 2005), cortico-striatal (Yeh et al. 2009), and cortico-pontine (Chanraud et al. 2009b) fibers are also affected in alcoholics relative to healthy controls.
