The largest DTI study of MBD to date included six study participants, five with a history of chronic alcoholism. All six showed hyperintense signals on diffusion images and low ADC of the corpus callosum. Researchers observed cortical lesions in frontoparietal regions in three of six study participants with the poorest outcomes (Menegon et al. 2005). Remaining DTI studies of MBD were case studies (e.g., Tuntiyatorn and Laothamatas 2008) showing low ADC along the entire corpus callosum (Bano et al. 2009; Wenz et al. 2014), with FA values diminishing progressively from front to back (Pacheco et al. 2014; Sair et al. 2006). No known DTI studies have been conducted in patients with ACD or ARD.
