Since 2018, DrugBank has expanded its reported drug coverage from just three geographic regions [the US (FDA), Canada (Health Canada) and the EU (European Medicines Agency)] to 11 geographic regions (Table 2). For each supported region, DrugBank matches the tempo of the public release of new information by the relevant drug agency, aligning them to existing DrugCards (if possible). If no DrugCard exists, a new one is created after confirmation that the product ingredient represents a new active ingredient not previously captured within DrugBank. Collectively, these eight new regions account for 223 127 of the 570 091 drug products in DrugBank (40% of DrugBank's total list of drug entities).