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Chunk #40 — 3. Results — 3.3. Motivational properties of alcohol

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Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.
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of trial; F(4, 115) = 3.9; p < .01, trial × treatment interaction] as well as for LPS-pretreated mice [F(1, 115) = 292; p < .001, effect of treatment; F(4, 115) = 6.5; p < .001, trial × treatment interaction] (Fig. 8A). However, in saline-treated groups LPS-pretreated mice consumed less saccharin than saline-pre-treated mice [F(1, 90) = 17.9, p < 0.001, effect of treatment; F(4, 90) = 5.2, p < 0.001, effect of trial]. Comparison mice from ethanol-treated groups also showed that LPS-pretreated mice consumed less saccharin than saline-pretreated mice [F(1, 140) = 5.9, p < .05, effect of treatment; F(4, 90) = 10.4, p < .001, effect of trial].