Using the threshold of p < 0.001 (Barrett et al. 2005), all SNPs conformed to HWE (Table 2 - 3). To determine if SNPs represented statistically independent loci, LD was examined. Supplementary Figures 1 - 4 present the LD found among the SNPs tested in both samples in the non-Hispanic EA and Hispanic subsets. SNPs rs1127314 and rs3766927 in CHRNB2 were highly correlated in both the CADD non-Hispanic EA and Hispanic sample (r2 = 0.99 - 1), but all other SNPs represent independent loci (r2≤0.70). Since rs1127314 and rs3766927 represent a single genetic signal, rs3766927 was not tested for association with ND.
