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Chunk #16 — MATERIALS AND METHODS — Statistical Methods — Statistical Analyses

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Nominal association with CHRNA4 variants and nicotine dependence.
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variable in a family-based association test carried out in the FBAT software package using an additive model (Laird et al. 2000). To correct for the testing of multiple SNPs, the min –p option in FBAT was used (Rakovski et al. 2007), this performs a permutation test to indicate the significance of the most significant statistic when corrected for multiple testing. The min –p correction was performed on the total number of SNPs tested across both genes.