We conducted two-factor repeated measure ANOVAs (or analyses of covariance [ANCOVAs], with dose as a repeated measure) for outcome measures stop RT, go RT, and POMS to compare the effect of individual SNPs on responses to drug (0, 5, 10, 20 mg). Because mood was measured at multiple time points, we calculated the area under the curve relative to baseline (Time 0), for each drug dose. We conducted post hoc analyses to identify the source of genotype–drug interactions.
