In a microarray study, McClintick and colleagues 9 compared gene expression in the hippocampus of 20 individuals with and 19 without AUD from the New South Wales Tissue Resource Centre. There were 639 named genes for which expression differed between those with and without AUD at a False Discovery Rate (FDR) ≤ 0.20. Although changes were small, 52% of those genes differed by at least 1.2‐fold. Among these were the glucocorticoid receptor, the related FK506 binding protein 5 (FKBP5) and many metallothioneins. Pathways related to inflammation, hypoxia, and stress showed activation, while pathways that play roles in neurogenesis and myelination showed decreases in expression. 9
