Concept profile overlaps are also used to provide lists of candidate genes for involvement in susceptibility to particular diseases. There is no gold standard for candidate genes for a disease, with different compilations using different criteria. Comparison of our hypertension list with a hand compiled list for essential hypertension [76], shows informative similarities and differences. That list contains 75 candidate genes rated as 'strong', 57 of which are also in the SNPs3D hypertension set. Nine of the top ten ranking SNPs3D genes are in the hand complied hypertension list. The exception is BMPR2, which is involved in pulmonary hypertension, rather than essential hypertension. The 12th ranking gene in the SNPs3D list, ADRB2, is also not in the hand complied list, but is clearly associated with hypertension in PubMed abstracts. Conversely, some of the additional genes in the hand complied list, such as GALR1, are not linked in any way to hypertension in PubMed, even with a more sophisticated profile based search, and including all abstracts. Their selection may reflect specialized insights on the part of the compliers. Others, such APOC2
