We found consistent evidence for genetic overlap between externalizing and suicide-related outcomes. Genetic correlations between MVP-EXT and suicide related outcomes across the EUR-like and AFR-like results had similar patterns of associations. MVP-EXT was strongly associated with suicide attempt in both populations, and results from MiXeR demonstrated that these are distinct phenotypes that have significant polygenic overlap. While MVP-EXT was only significantly associated with suicidal ideation in the EUR-like results, the confidence intervals overlapped with those in the AFR-like results, suggesting that this may be the result of the lower power in the AFR-like results. In the polygenic score analyses, the association between MVP-EXT PGS and suicide-related outcomes was null for the AFR-like participants. There are several possible explanations for this lack of association. First, it is possible we did not have sufficient power, as seen in the genetic correlation with ideation in the AFR-like participants. Second, our results are primarily derived from EHR. Marginalized racial and ethnic populations receive less engagement in EHR (e.g., fewer number of EHR actions performed within a patient’s EHR per hour) compared to those who
