Fig. 1 illustrates results from the polygenic risk score analysis. The figure shows, for each p value threshold the number of variants included in the risk score, the p value threshold, and the correlation estimate between the endophenotype and the polygenic risk score. The only polygenic risk score association approaching significance was that between the score based on the top 127 variants and overall startle (p ~ 0.005), which does not survive a correction for multiple testing of 17 endophenotypes (0.05/17 = 0.003), let alone for multiple testing of 17 endophenotypes and nine p value thresholds.
