The role of PS1 in neurogenesis may be γ-secretase-dependent, at least in part. Treatment with γ-secretase inhibitor enhances neuronal differentiation of embryonic stem cells (Ma et al., 2008). In addition, treatment with a γ-secretase inhibitor reduces the extent of proliferation of mesenchymal stem cells and alters their differentiation (Vujovic et al., 2007).
