One further region deserves comment. In the multilocus analysis, there was increased support for a region on chromosome 12p13 containing several candidate genes, including CD69 (CD69 antigen (p60, early T-cell activation antigen)) and multiple CLEC (C-type lectin domain family) genes. In contrast to the chromosome 4 region where the effect of impuation is to tip an already-strong signal (5.01×10-7 for typed rs17388568, trend test) over the arbitrary threshold of 5×10-7, the 12p13 locus involves a more marked change between imputed and actual (7.2×10-7 for rs11052552, general test). Replication studies of this imputed SNP to date have produced equivocal results (for details see ref. 10).
