Type 2 diabetes is a chronic metabolic disorder typically first diagnosed in the middle to late adult years100. Strongly associated with obesity, the condition features defects in both the secretion and peripheral actions of insulin101. The appareciable familial aggregation of T2D (an estimated λs of ~3.0 in European individuals)73 reflects both shared family environment and genetic predisposition. Heritability values vary widely with most estimates between 30 and 70%101.
