Chunk #71 — Disease association results — Type 2 diabetes (T2D)

Source

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

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To date, robust, widely replicated associations in non-isolate populations are limited to variants in three genes: PPARG (encoding the peroxisomal proliferative activated receptor gamma; P12A102), KCNJ11 (the inwardly-rectifying Kir6.2 component of the pancreatic beta-cell KATP channel; E23K103) and TCF7L2 (transcription factor 7-like 2; rs7903146 (refs 104​,​ ​105)).