Recent genome-wide association studies (GWAS) for AUD and related traits have identified trait-associated genes and facilitated the creation of PGS that capture individual’s genetic liability for a trait, calculated by summing associated risk variants across the genome and weighting by their effect sizes (Khera et al., 2018, Lai et al., 2022a, Lai et al., 2022b). We have developed an AUD PGS (PGSAUD) by using only concordant variants among different studies that can evaluate AUD risk at a level comparable to that associated with first-degree family history of AUD in an EA sample (Lai et al., 2022a). We also developed a PGSAUD for use in AA populations by utilizing population-concordant variants, with dramatically increased performance compared to current AA PGSAUD (Lai et al., 2022b). In our previous study, we found that PGSAUD was positively associated with AUD severity as measured by DSM-5 AUD criterion counts (Lai et al., 2022a). Since AUD severity is negatively associated with remission (Fan et al., 2019b, Dawson et al., 2005, Lee et al., 2018), we hypothesized that PGSAUD would be negatively associated with the probability of
