DSM-5 AUD criterion counts (Lai et al., 2022a). Since AUD severity is negatively associated with remission (Fan et al., 2019b, Dawson et al., 2005, Lee et al., 2018), we hypothesized that PGSAUD would be negatively associated with the probability of remission from AUD. We tested our hypothesis by using COGA samples consisting of participants with diagnostic interview defined DSM-5 AUD from families enriched with AUDs and comparison families not enriched for but not excluding AUDs. Importantly, we adjusted for covariates that index AUD severity to partition out behavioral indicators of severity from the genetic liability indexed by PGSAUD. We also included treatment history and history of remission in family members as sources of information on the course of AUD that are complementary to PGSAUD. Additionally, we tested our hypothesis using two cohorts from Indiana Biobank that were selected for the study of liver diseases and substance use disorders, respectively, and not ascertained for studying AUD, in order to determine whether our hypothesis is supported in samples with different ascertainment strategies. This study is pre-registered at the Open Science Framework (osf.io/x8ct6).
