Electrophysiological functional analysis has high-time resolution and thus is important to reveal the pathology associated with synaptic dysfunction. Ability to investigate these changes offers an additional level of information over most current models34. By using an optogenetic approach, we can record from one neuronal subtype after stimulating another subtype (in this case, an excitatory to inhibitory circuit connection). We have therefore created a subtype-specific functional neurocircuit using human-induced neurons.
