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Chunk #21 — RESULTS — 1. Epigenetic Marks Transition from Quiescent to Differentiation — Histone modifications

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Cellular epigenetic modifications of neural stem cell differentiation.
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periphery and proximal areas (Table 1, Figure 2 top panel, compare E, F, G; periphery, migrated proximal, migrated distal, respectively). Many of the migrated population of 2me-H3K4+ cells also expressed PCNA, indicating continued proliferation at the time of subplating. Double-staining with nestin revealed a co-localization of 2me-H3K4 in the migrated population, although some of the nestin+ cells had very low levels of 2me-H3K4.