Furthermore, the magnitude of risk conferred by high GPS increased at more extreme levels of observed obesity. The proportion of high GPS carriers was 9.7% among individuals with BMI < 40 kg/m2; 31% among the 5,232 individuals with BMI ≥ 40 kg/m2; 42.3% among the 331 individuals with BMI ≥ 50 kg/m2; and 61.5% among the 26 individuals with BMI ≥ 60 kg/m2. Compared with the remainder of the GPS distribution, high GPS was associated with a 4.2, 6.6, and 14.4-fold increased risk of BMI ≥ 40, 50, and 60 kg/m2, respectively (Figure 3B).
