We sought to mimic this approach using the GPS by labeling the top decile of the GPS distribution as ‘carriers’ and those in the remainder of the distribution as non-carriers (Figure 3A). The 10% of the population who carried ‘high GPS’ demonstrated an average BMI that was 2.9 kg/m2 higher and weight 8.0 kilograms higher than noncarriers (p < 0.0001 for both comparisons). Results were similar when high GPS carriers were compared to individuals within the middle quintile of the score distribution instead of the bottom 90% of the distribution, with difference in BMI and weight of 2.6 kg/m2 and 7.4 kilograms, respectively.
