The features of NR and LR neurons were so different that they led us to believe that the patient’s responsiveness to Li could be predicted based on electrophysiological measurements alone. We therefore constructed an NB model that trained on five patients and predicted a new patient’s response to Li with a remarkable accuracy and with an area under the curve of 0.98 using an receiver-operating characteristics curve, where features used for classification were extracted from 3- or 5-cell recordings (Figure 4). These findings not only strengthen the observation that NR and LR neurons have very different intrinsic properties but also may have direct medical applicability for any new patient who needs to be classified as LR or NR.
