Figure 4 shows side-by-side Manhattan plots from the GWAS and MTAG analyses for each trait. Approximately independent genome-wide significant SNPs, hereafter “lead SNPs,” were defined by clumping with an R2 threshold of 0.1 (Online Methods). From GWAS to MTAG, the number of lead SNPs increases from 32 to 64 for DEP, from 9 to 37 for NEUR, and from 13 to 49 for SWB.
