For the MTAG hits, we calculate the maxFDR assuming that at least 10% of SNPs are non-null for each trait (our estimates of the actual percentage non-null are 59-65% across the three traits; Online Methods). The maxFDR is 0.0014 for DEP, 0.0080 for NEUR, and 0.0044 for SWB. This calculation suggests that the hits are unlikely to be an artifact of the homogeneous-Ω assumption.
