implications of the genetic effects of variants in KCNJ6 on posterior theta EROs as possible “protective” or “risk” factors and the behavioral and clinical implications, and as indices of delays in brain maturation (i.e., lack of frontalization). Furthermore, functional studies are underway in COGA with KCNJ6 variants and 1) single cell electrophysiology, as well as 2) induced pluripotent stem cells (iPSC) derived neurons generated from the human participants of COGA with several KCNJ6 variants to examine acute and chronic effects of alcohol.
