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Chunk #45 — 4. Discussion — 4.5. Limitations of the current study and suggestion for future studies

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A KCNJ6 gene polymorphism modulates theta oscillations during reward processing.
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Although the current study has found that the KCNJ6 SNP (rs702859) is associated with reward related theta EROs, it has a few limitations. While the sample size of the current study appears large, it may not be sufficiently large for a genetic study to test multiple hypotheses involving several factors. Only a single KCNJ6 SNP has been explored in this study. Further studies exploring genetic effects on developmental trajectories of EROs from multiple task paradigms, including the monetary gambling task, are underway, and may offer important clues to better understand these factors. Future studies including the behavioral aspects associated with reward processing (e.g., risk-taking, decision making, reaction time, etc.) and clinical features (e.g., externalizing and internalizing) may offer valuable clues underlying connections between KCNJ6, risk propensity, brain oscillations, and potential clinical outcomes. Future studies are also needed to determine the implications of the genetic effects of variants in KCNJ6 on posterior theta EROs as possible “protective” or “risk” factors and the behavioral and clinical implications, and as indices of delays in brain maturation (i.e., lack of frontalization). Furthermore, functional studies