Chunk #22 — Method — Genotyping and Imputation

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The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption.

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Of the 92 SNPs used in the SNP score, 28 were available on the Illumina 660W quad array used in the full sample. The remaining SNPs were imputed with MaCH (Li, Willer, Sanna, & Abecasis, 2009; Li, Willer, Ding, Scheet, & Abecasis, 2010) based on the August 2010 reference haplotypes, each with satisfactory imputation quality (mean r2 = .92; median = .96; SD = .11; range = [0.52, 1.0]).